Ontology highlight
ABSTRACT:
SUBMITTER: Boubakri H
PROVIDER: S-EPMC2770101 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Boubakri Hasna H de Septenville Anne Langlois AL Viguera Enrique E Michel Bénédicte B
The EMBO journal 20091022 1
How living cells deal with head-on collisions of the replication and transcription complexes has been debated for a long time. Even in the widely studied model bacteria Escherichia coli, the enzymes that take care of such collisions are still unknown. We report here that in vivo, the DinG, Rep and UvrD helicases are essential for efficient replication across highly transcribed regions. We show that when rRNA operons (rrn) are inverted to face replication, the viability of the dinG mutant is affe ...[more]