Loss of hypocretin (orexin) neurons with traumatic brain injury.
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ABSTRACT:
SUBMITTER: Baumann CR
PROVIDER: S-EPMC2770195 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Loss of hypocretin (orexin) neurons with traumatic brain injury.
Baumann Christian R CR Bassetti Claudio L CL Valko Philipp O PO Haybaeck Johannes J Keller Morten M Clark Erika E Stocker Reto R Tolnay Markus M Scammell Thomas E TE
Annals of neurology 20091001 4
Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the hypothalamic neurons that produce the wake-promoting neuropeptide hypocretin (orexin) causes the severe sleepiness of narcolepsy, and partial loss of these cells may contribute to the sleepiness of Parkinson disease and other disorders. We have found that the number of hypocretin neurons is significantly reduced in ...[more]
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