Ontology highlight
ABSTRACT:
SUBMITTER: Takaine M
PROVIDER: S-EPMC2771088 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Takaine Masak M Numata Osamu O Nakano Kentaro K
The EMBO journal 20090827 20
The contractile ring (CR) consists of bundled actin filaments and myosin II; however, the actin-bundling factor remains elusive. We show that the fission yeast Schizosaccharomyces pombe IQGAP Rng2 is involved in the generation of CR F-actin and required for its arrangement into a ring. An N-terminal fragment of Rng2 is necessary for the function of Rng2 and is localized to CR F-actin. In vitro the fragment promotes actin polymerization and forms linear arrays of F-actin, which are resistant to t ...[more]