Ontology highlight
ABSTRACT:
SUBMITTER: Thiebeauld O
PROVIDER: S-EPMC2771092 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Thiébeauld Odon O Schepetilnikov Mikhail M Park Hyun-Sook HS Geldreich Angèle A Kobayashi Kappei K Keller Mario M Hohn Thomas T Ryabova Lyubov A LA
The EMBO journal 20090910 20
The plant viral re-initiation factor transactivator viroplasmin (TAV) activates translation of polycistronic mRNA by a re-initiation mechanism involving translation initiation factor 3 (eIF3) and the 60S ribosomal subunit (60S). QJ;Here, we report a new plant factor-re-initiation supporting protein (RISP)-that enhances TAV function in re-initiation. RISP interacts physically with TAV in vitro and in vivo. Mutants defective in interaction are less active, or inactive, in transactivation and viral ...[more]