Ontology highlight
ABSTRACT:
SUBMITTER: Forster F
PROVIDER: S-EPMC2771176 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Förster Friedrich F Lasker Keren K Beck Florian F Nickell Stephan S Sali Andrej A Baumeister Wolfgang W
Biochemical and biophysical research communications 20090803 2
The 26S proteasome is the most downstream element of the ubiquitin-proteasome pathway of protein degradation. It is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP consists of 6 AAA-ATPases and at least 13 non-ATPase subunits. Based on a cryo-EM map of the 26S proteasome, structures of homologs, and physical protein-protein interactions we derive an atomic model of the AAA-ATPase-CP sub-complex. The ATPase order in our model (Rpt1/Rpt2/Rpt6/Rpt3/Rpt4/Rpt5) is ...[more]