Ontology highlight
ABSTRACT:
SUBMITTER: Staples GO
PROVIDER: S-EPMC2771417 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Staples Gregory O GO Bowman Michael J MJ Costello Catherine E CE Hitchcock Alicia M AM Lau James M JM Leymarie Nancy N Miller Christine C Naimy Hicham H Shi Xiaofeng X Zaia Joseph J
Proteomics 20090201 3
A key challenge to investigations into the functional roles of glycosaminoglycans (GAGs) in biological systems is the difficulty in achieving sensitive, stable, and reproducible mass spectrometric analysis. GAGs are linear carbohydrates with domains that vary in the extent of sulfation, acetylation, and uronic acid epimerization. It is of particular importance to determine spatial and temporal variations of GAG domain structures in biological tissues. In order to analyze GAGs from tissue, it is ...[more]