Dataset Information

Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant.

ABSTRACT:

Background

Established indicators of central obesity include waist circumference, waist/height ratio, and the conicity index. Studies using such measures (as opposed to body mass index [BMI] percentiles) to characterize the association between obesity and asthma are lacking, despite the fact that these measures have been shown to be most relevant for many other chronic diseases.

Objectives

We sought to examine measures assessing the distribution of obesity in the context of childhood allergic rhinitis and asthma and to elucidate the association of obesity, including central obesity, with allergic asthma in children.

Methods

Children with allergic rhinitis with (cases) or without (control subjects) asthma were recruited. BMI percentiles were derived by using national growth charts. Waist circumference, waist/height ratio, and conicity index values were obtained.

Results

Central obesity was associated with asthma, asthma severity, lower lung function, and reduced atopy in asthmatic subjects.

Conclusion

Measures of central obesity are more associated with the presence of asthma and asthma severity in children with allergic rhinitis when compared with standard BMI measures.

SUBMITTER: Musaad SM

PROVIDER: S-EPMC2771544 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Publications

Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant.

Musaad Salma M A SM Patterson Tia T Ericksen Mark M Lindsey Mark M Dietrich Kim K Succop Paul P Khurana Hershey Gurjit K GK

The Journal of allergy and clinical immunology 20090512 6

<h4>Background</h4>Established indicators of central obesity include waist circumference, waist/height ratio, and the conicity index. Studies using such measures (as opposed to body mass index [BMI] percentiles) to characterize the association between obesity and asthma are lacking, despite the fact that these measures have been shown to be most relevant for many other chronic diseases.<h4>Objectives</h4>We sought to examine measures assessing the distribution of obesity in the context of childh ...[more]

PMID: 19439348

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Project description:BackgroundSpecific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk.ObjectiveTo define relationships among established sensitization to particular aeroallergens, quantitative analyses of allergen-specific IgE levels, pet exposure and sensitization, and asthma and rhinitis risk.MethodsChildren at high-risk for the development of asthma and allergic diseases were enrolled at birth into the Childhood Origins of ASThma (COAST) study. Allergen-specific IgE was assessed at ages 1, 3, 6, and 9 years by fluoroenzyme immunoassay (Unicap(®) 100; Pharmacia Diagnostics). Current asthma and rhinitis were diagnosed at age 6 and 8 years.ResultsSensitization to dog was strongly associated with increased asthma risk (P < 0.0001). Sensitization to perennial compared with seasonal allergens was more strongly associated with asthma risk, while sensitization to seasonal allergens was more closely associated with rhinitis risk. Increased levels of specific IgE to perennial allergens were associated with an increased asthma risk (P = 0.05), while any detectable level of IgE to seasonal allergens was associated with increased rhinitis risk (P = 0.0009). While dog and cat sensitization were both independently associated with increased asthma and rhinitis risk, dog exposure at birth was associated with a reduced risk of asthma, regardless of dog sensitization status during the first 6 years of life (P = 0.05).Conclusions and clinical relevanceAnalysing specific patterns of an individual's allergic sensitization profile reveals additional relevant associations with asthma and rhinitis risk as opposed to the information gained from characterizing an individual as 'atopic' by the presence of any demonstrable sensitization alone. Furthermore, protective mechanisms of dog exposure with regards to asthma risk appear to be unrelated to the prevention of sensitization.

Dataset Information

Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant.

Background

Objectives

Methods

Results

Conclusion

Publications

Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant.

Similar Datasets

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