Dataset Information

Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism.

ABSTRACT: Fat-induced hepatic insulin resistance (FIHIR) in obesity induced by high-fat diet leads to ectopic lipid accumulation and may contribute to the pathogenesis of type 2 diabetes. We examined the alterations in hepatic gene expression involved in FIHIR by using obese insulin-resistant and diabetic hamsters that received high-fat diet with or without low-dose streptozotocin. Microarray analysis and confirmatory real-time RT-PCR indicated that increased mRNA levels of sterol regulatory element-binding proteins (SREBPs) and decreased mRNA levels of liver X receptor (LXRalpha) and peroxisome-proliferator-activated receptor (PPARalpha) occurred in FIHIR in insulin-resistant and diabetic hamsters. Expression levels of hepatic LXRalpha, SREBPs, and PPARalpha differed significantly between insulin-resistant and diabetic hamsters. Expression of LXRalpha, SREBPs, and PPARalpha all change in FIHIR associated with hepatic lipid accumulation in insulin-resistant and diabetic hamsters in which disease is induced by high-fat diet and streptozotocin injection.

SUBMITTER: Li G

PROVIDER: S-EPMC2771602 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism.

Li Guosheng G Liu Xuhan X Zhu Hua H Huang Lan L Liu Yali Y Ma Chunmei C Qin Chuan C

Comparative medicine 20091001 5

Fat-induced hepatic insulin resistance (FIHIR) in obesity induced by high-fat diet leads to ectopic lipid accumulation and may contribute to the pathogenesis of type 2 diabetes. We examined the alterations in hepatic gene expression involved in FIHIR by using obese insulin-resistant and diabetic hamsters that received high-fat diet with or without low-dose streptozotocin. Microarray analysis and confirmatory real-time RT-PCR indicated that increased mRNA levels of sterol regulatory element-bindi ...[more]

PMID: 19887029

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Dataset Information

Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism.

Publications

Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism.

Similar Datasets

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