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Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide a.

ABSTRACT: The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S.

SUBMITTER: Rubio BK

PROVIDER: S-EPMC2772108 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide a.

Rubio Brent K BK Robinson Sarah J SJ Avalos Claudia E CE Valeriote Frederick A FA de Voogd Nicole J NJ Crews Phillip P

Journal of natural products 20080701 8

The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereo ...[more]

PMID: 18590311

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