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A novel picornavirus associated with gastroenteritis.

ABSTRACT: A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide similarity, named klassevirus, were also recently reported in three cases of unexplained diarrhea from the United States and Australia and in sewage from Spain, reflecting a global distribution and supporting a pathogenic role for this new group of picornaviruses.

SUBMITTER: Li L

PROVIDER: S-EPMC2772710 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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A novel picornavirus associated with gastroenteritis.

Li Linlin L Victoria Joseph J Kapoor Amit A Blinkova Olga O Wang Chunlin C Babrzadeh Farbod F Mason Carl J CJ Pandey Prativa P Triki Hinda H Bahri Olfa O Oderinde Bamidele Soji BS Baba Marycelin Mandu MM Bukbuk David Nadeba DN Besser John M JM Bartkus Joanne M JM Delwart Eric L EL

Journal of virology 20090916 22

A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide ...[more]

PMID: 19759142

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A novel picornavirus associated with gastroenteritis.

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A novel picornavirus associated with gastroenteritis.

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