Analysis of short tandem repeats by parallel DNA threading.
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ABSTRACT:
SUBMITTER: Zajac P
PROVIDER: S-EPMC2773041 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Analysis of short tandem repeats by parallel DNA threading.
Zajac Pawel P Oberg Christine C Ahmadian Afshin A
PloS one 20091113 11
The majority of studies employing short tandem repeats (STRs) require investigation of several of these genetic markers. As such, we demonstrate the feasibility of the trinucleotide threading (TnT) approach for scalable analysis of STRs. The TnT method represents a parallel amplification alternative that addresses the obstacles associated with multiplex PCR. In this study, analysis of the STR fragments was performed with capillary gel electrophoresis; however, it should be possible to combine ou ...[more]
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