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The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.

ABSTRACT: The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.

SUBMITTER: Vilborg A 

PROVIDER: S-EPMC2773521 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.

Vilborg Anna A   Glahder Jacob A JA   Wilhelm Margareta T MT   Bersani Cinzia C   Corcoran Martin M   Mahmoudi Salah S   Rosenstierne Maiken M   Grandér Dan D   Farnebo Marianne M   Norrild Bodil B   Wiman Klas G KG  

Proceedings of the National Academy of Sciences of the United States of America 20090901 37

The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the  ...[more]

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