Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2773972 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Liu Xuefeng X Dakic Aleksandra A Zhang Yiyu Y Dai Yuhai Y Chen Renxiang R Schlegel Richard R
Proceedings of the National Academy of Sciences of the United States of America 20091020 44
Telomerase activation is critical for the immortalization of primary human keratinocytes by the high-risk HPV E6 and E7 oncoproteins, and this activation is mediated in part by E6-induction of the hTERT promoter. E6 induces the hTERT promoter via interactions with the cellular ubiquitin ligase, E6AP, and with the c-Myc and NFX-1 proteins, which are resident on the promoter. In the current study we demonstrate that E6 protein interacts directly with the hTERT protein. Correlating with its ability ...[more]