Dataset Information

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

ABSTRACT:

Background

Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA([Ser]Sec).

Results

To define macrophage-specific selenoprotein functions, we generated mice with the Sec tRNA([Ser]Sec) gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophages in a protein gel matrix.

Conclusion

Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages.

SUBMITTER: Carlson BA

PROVIDER: S-EPMC2774298 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Publications

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

Carlson Bradley A BA Yoo Min-Hyuk MH Sano Yasuyo Y Sengupta Aniruddha A Kim Jin Young JY Irons Robert R Gladyshev Vadim N VN Hatfield Dolph L DL Park Jin Mo JM

BMC immunology 20091028

<h4>Background</h4>Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA([Ser]Sec).<h4>Results</h4>To define macrophage-specific selenoprotein functions, we generated mice with the Sec tRNA([Ser]Sec) gene ...[more]

PMID: 19863805

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Dataset Information

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

Background

Results

Conclusion

Publications

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

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