Ontology highlight
ABSTRACT:
SUBMITTER: Kalinke U
PROVIDER: S-EPMC27744 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Kalinke U U Oxenius A A Lopez-Macias C C Zinkernagel R M RM Hengartner H H
Proceedings of the National Academy of Sciences of the United States of America 20000801 18
Mice infected with vesicular stomatitis virus (VSV), a cytopathic virus closely related to rabies virus, mount a virus-neutralizing antibody response protecting against lethal disease. VSVneutralizing monoclonal IgGs isolated from primary immune responses were devoid of somatic mutations, whereas most secondary and all hyperimmune response IgGs tested were hypermutated. A comparative analysis of recombinant single-chain antibody fragments (scFv-Ckappa) revealed that even the germ-line precursor ...[more]