Ontology highlight
ABSTRACT:
SUBMITTER: Adams DG
PROVIDER: S-EPMC2774688 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Adams Deanna G DG Wang Yu Y Mak Puiying A PA Chyba Jason J Shalizi Orzala O Matzen Jason J Anderson Paul P Smith Tim R TR Garcia Michael M Welch Genevieve L GL Claret Emmanuel J EJ Fink Michel M Orth Anthony P AP Caldwell Jeremy S JS Brinker Achim A
Current chemical genomics 20080523
High-throughput cellular profiling has successfully stimulated early drug discovery pipelines by facilitating targeted as well as opportunistic lead finding, hit annotation and SAR analysis. While automation-friendly universal assay formats exist to address most established drug target classes like GPCRs, NHRs, ion channels or Tyr-kinases, no such cellular assay technology is currently enabling an equally broad and rapid interrogation of the Ser/Thr-kinase space. Here we present the foundation o ...[more]