Ontology highlight
ABSTRACT:
SUBMITTER: Setoguchi R
PROVIDER: S-EPMC2774709 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Setoguchi Ruka R Taniuchi Ichiro I Bevan Michael J MJ
Journal of immunology (Baltimore, Md. : 1950) 20090904 7
In the thymus, the transcription factor ThPOK is essential for the development of the CD4 helper T cell lineage, whereas active repression of ThPOK is critical for the development of the CD8 cytotoxic T cell lineage. ThPOK gene silencing is thought to be irreversible in peripheral CD8 T cells. We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role for ThPOK in the CD8 T cell response to an ...[more]