Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals.
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SUBMITTER: Kahn R
PROVIDER: S-EPMC2774896 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals.
Kahn Roberta R Biswas Kousick K Childress Anna-Rose AR Shoptaw Steve S Fudala Paul J PJ Gorgon Liza L Montoya Ivan I Collins Joseph J McSherry Frances F Li Shou-Hua SH Chiang Nora N Alathari Husam H Watson Donnie D Liberto Joseph J Beresford Thomas T Stock Christopher C Wallace Christopher C Gruber Valerie V Elkashef Ahmed A
Drug and alcohol dependence 20090502 1-2
<h4>Background</h4>Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment. Baclofen is a GABA(B) receptor agonist that in preclinical and early pilot clinical trials has shown promise for the treatment of cocaine dependence. The purpose of this multi-site, double-blind study, was to compare the safety and efficacy of baclofen (60 mg/day) vs placebo in an 8-week treatment of individuals with severe cocaine dependence. The primary outcome m ...[more]
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