Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
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ABSTRACT:
SUBMITTER: Lamb A
PROVIDER: S-EPMC2775174 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
Lamb Acacia A Yang Xiao-Dong XD Tsang Ying-Hung N YH Li Jiang-Dong JD Higashi Hideaki H Hatakeyama Masanori M Peek Richard M RM Blanke Steven R SR Chen Lin-Feng LF
EMBO reports 20091009 11
Helicobacter pylori-initiated chronic gastritis is characterized by the cag pathogenicity island-dependent upregulation of proinflammatory cytokines, which is largely mediated by the transcription factor nuclear factor (NF)-kappaB. However, the cag pathogenicity island-encoded proteins and cellular signalling molecules that are involved in H. pylori-induced NF-kappaB activation and inflammatory response remain unclear. Here, we show that H. pylori virulence factor CagA and host protein transform ...[more]
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