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Stable encoding of task structure coexists with flexible coding of task events in sensorimotor striatum.

ABSTRACT: The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in the sensorimotor striatum is thought to underlie not only normal habits but also addiction and clinical syndromes characterized by behavioral fixity. By recording in the sensorimotor striatum of mice, we asked whether neuronal activity acquired during procedural learning would be stable even if the sensory stimuli triggering the habitual behavior were altered. Contrary to expectation, both fixed and flexible activity patterns appeared. One, representing the global structure of the acquired behavior, was stable across changes in task cuing. The second, a fine-grain representation of task events, adjusted rapidly. Such dual forms of representation may be critical to allow motor and cognitive flexibility despite habitual performance.

SUBMITTER: Kubota Y

PROVIDER: S-EPMC2775375 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Stable encoding of task structure coexists with flexible coding of task events in sensorimotor striatum.

Kubota Yasuo Y Liu Jun J Hu Dan D DeCoteau William E WE Eden Uri T UT Smith Anne C AC Graybiel Ann M AM

Journal of neurophysiology 20090722 4

The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in the sensorimotor striatum is thought to underlie not only normal habits but also addiction and clinical syndromes characterized by behavioral fixity. By recording in the sensorimotor striatum of mice, we ask ...[more]

PMID: 19625536

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Project description:Human performance shows substantial endogenous variability over time, and this variability is a robust marker of individual differences. Of growing interest to psychologists is the realisation that variability is not fully random, but often exhibits temporal dependencies. However, their measurement and interpretation come with several controversies. Furthermore, their potential benefit for studying individual differences in healthy and clinical populations remains unclear. Here, we gather new and archival datasets featuring 11 sensorimotor and cognitive tasks across 526 participants, to examine individual differences in temporal structures. We first investigate intra-individual repeatability of the most common measures of temporal structures - to test their potential for capturing stable individual differences. Secondly, we examine inter-individual differences in these measures using: (1) task performance assessed from the same data, (2) meta-cognitive ratings of on-taskness from thought probes occasionally presented throughout the task, and (3) self-assessed attention-deficit related traits. Across all datasets, autocorrelation at lag 1 and Power Spectra Density slope showed high intra-individual repeatability across sessions and correlated with task performance. The Detrended Fluctuation Analysis slope showed the same pattern, but less reliably. The long-term component (d) of the ARFIMA(1,d,1) model showed poor repeatability and no correlation to performance. Overall, these measures failed to show external validity when correlated with either mean subjective attentional state or self-assessed traits between participants. Thus, some measures of serial dependencies may be stable individual traits, but their usefulness in capturing individual differences in other constructs typically associated with variability in performance seems limited. We conclude with comprehensive recommendations for researchers.Supplementary informationThe online version contains supplementary material available at 10.1007/s42113-022-00162-1.

Dataset Information

Stable encoding of task structure coexists with flexible coding of task events in sensorimotor striatum.

Publications

Stable encoding of task structure coexists with flexible coding of task events in sensorimotor striatum.

Similar Datasets

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