Ontology highlight
ABSTRACT:
SUBMITTER: Meyn MA
PROVIDER: S-EPMC2775445 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Meyn Malcolm A MA Smithgall Thomas E TE
Science signaling 20091013 92
Multiple Src family kinases (SFKs) are present in murine embryonic stem (mES) cells. Whereas complete inhibition of SFK activity blocks mES cell differentiation, sole inhibition of the SFK member c-Yes induces differentiation. Thus, individual SFKs may have opposing roles in the regulation of mES cell fate. To test this possibility, we generated SFK mutants with engineered resistance to a nonselective SFK inhibitor. The presence of an inhibitor-resistant c-Src mutant, but not analogous mutants o ...[more]