Ontology highlight
ABSTRACT:
SUBMITTER: Nativio R
PROVIDER: S-EPMC2776306 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Nativio Raffaella R Wendt Kerstin S KS Ito Yoko Y Huddleston Joanna E JE Uribe-Lewis Santiago S Woodfine Kathryn K Krueger Christel C Reik Wolf W Peters Jan-Michael JM Murrell Adele A
PLoS genetics 20091126 11
Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood. In mammalian genomes, cohesin co-localizes with CCCTC binding factor (CTCF), a zinc finger protein implicated in multiple gene regulatory events. At the imprinted IGF2-H19 locus, CTCF plays an important role in organizing allele-specific higher-order c ...[more]