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A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.


ABSTRACT: Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.

SUBMITTER: Gao W 

PROVIDER: S-EPMC2776380 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.

Gao Wei W   Hillwig Matthew L ML   Huang Luqi L   Cui Guanghong G   Wang Xueyong X   Kong Jianqiang J   Yang Bin B   Peters Reuben J RJ  

Organic letters 20091101 22


Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydrox  ...[more]

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