Ontology highlight
ABSTRACT:
SUBMITTER: Gao W
PROVIDER: S-EPMC2776380 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Gao Wei W Hillwig Matthew L ML Huang Luqi L Cui Guanghong G Wang Xueyong X Kong Jianqiang J Yang Bin B Peters Reuben J RJ
Organic letters 20091101 22
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydrox ...[more]