Ontology highlight
ABSTRACT:
SUBMITTER: Ivanova MI
PROVIDER: S-EPMC2776439 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Ivanova Magdalena I MI Sievers Stuart A SA Sawaya Michael R MR Wall Joseph S JS Eisenberg David D
Proceedings of the National Academy of Sciences of the United States of America 20091028 45
In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the smallest segment that both nucleates and inhibits the fibrillation of full-length insulin in a molar ratio-dependent manner, suggesting that this segment is central to the cross-beta spine of the insulin fibril. In isolation from the rest of the protein, LVEALYL forms microcrystalline aggregates with fibrillar mor ...[more]