Ontology highlight
ABSTRACT:
SUBMITTER: Du JL
PROVIDER: S-EPMC2776453 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Du Jiu-lin JL Wei Hong-ping HP Wang Zuo-ren ZR Wong Scott T ST Poo Mu-ming MM
Proceedings of the National Academy of Sciences of the United States of America 20091103 45
Neural activity can induce persistent strengthening or weakening of synapses, known as long-term potentiation (LTP) or long-term depression (LTD), respectively. As potential cellular mechanisms underlying learning and memory, LTP and LTD are generally regarded as synapse-specific "imprints" of activity, although there is evidence in vitro that LTP/LTD may spread to adjacent synapses. Here, we report that LTP and LTD induced in vivo at retinotectal synapses of Xenopus tadpoles undergo rapid long- ...[more]