Ontology highlight
ABSTRACT:
SUBMITTER: Mavromatis K
PROVIDER: S-EPMC2776528 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Mavromatis Konstantinos K Chu Ken K Ivanova Natalia N Hooper Sean D SD Markowitz Victor M VM Kyrpides Nikos C NC
PloS one 20091124 11
Computational methods for determining the function of genes in newly sequenced genomes have been traditionally based on sequence similarity to genes whose function has been identified experimentally. Function prediction methods can be extended using gene context analysis approaches such as examining the conservation of chromosomal gene clusters, gene fusion events and co-occurrence profiles across genomes. Context analysis is based on the observation that functionally related genes are often hav ...[more]