Ontology highlight
ABSTRACT:
SUBMITTER: Andersson ME
PROVIDER: S-EPMC2776535 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Andersson Malin E ME Zetterberg Madeleine M Tasa Gunnar G Seibt-Palmér Mona M Juronen Erkki E Teesalu Pait P Blennow Kaj K Zetterberg Henrik H
Molecular vision 20070627
<h4>Purpose</h4>Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis.<h4>Methods</h4>Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 cont ...[more]