Ontology highlight
ABSTRACT:
SUBMITTER: Phan TG
PROVIDER: S-EPMC2776777 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Phan Tri Giang TG Green Jesse A JA Gray Elizabeth E EE Xu Ying Y Cyster Jason G JG
Nature immunology 20090607 7
Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined. Here we show SCS macrophage development depended on lymphotoxin-alpha1beta2, and the cells had low lysosomal enzyme expression and retained opsonized antigens on their surface. Intravital imaging revealed immune complexes moving along macrophage processes into the follicle. Moreover, noncognate B cells ...[more]