Ontology highlight
ABSTRACT:
SUBMITTER: Levin A
PROVIDER: S-EPMC2777023 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Levin Aviad A Hayouka Zvi Z Brack-Werner Ruth R Volsky David J DJ Friedler Assaf A Loyter Abraham A
Protein engineering, design & selection : PEDS 20091029 12
Following fusion of the human immunodeficiency virus type-1 (HIV-1) with host cells' membrane and reverse transcription of the viral RNA, the resulted cDNA is integrated into the host genome by the viral integrase enzyme (IN). Quantitative estimations have revealed that only 1-2 copies are integrated per infected cell, although many copies of the viral RNA are reverse-transcribed. The molecular mechanism that restricts the integration degree has not, so far, been elucidated. Following integratio ...[more]