Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.
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ABSTRACT:
SUBMITTER: Moran JL
PROVIDER: S-EPMC2777648 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.
Moran Jennifer L JL Shifley Emily T ET Levorse John M JM Mani Shyamala S Ostmann Kristin K Perez-Balaguer Ariadna A Walker Dawn M DM Vogt Thomas F TF Cole Susan E SE
Developmental dynamics : an official publication of the American Association of Anatomists 20090701 7
Tight regulation of Notch pathway signaling is important in many aspects of embryonic development. Notch signaling can be modulated by expression of fringe genes, encoding glycosyltransferases that modify EGF repeats in the Notch receptor. Although Lunatic fringe (Lfng) has been shown to play important roles in vertebrate segmentation, comparatively little is known regarding the developmental functions of the other vertebrate fringe genes, Radical fringe (Rfng) and Manic fringe (Mfng). Here we r ...[more]
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