Maternal neutralizing antibody and transmission of hepatitis C virus to infants.
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ABSTRACT:
SUBMITTER: Dowd KA
PROVIDER: S-EPMC2777710 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Maternal neutralizing antibody and transmission of hepatitis C virus to infants.
Dowd Kimberly A KA Hershow Ronald C RC Yawetz Sigal S Larussa Philip P Diaz Clemente C Landesman Sheldon H SH Paul Mary E ME Read Jennifer S JS Lu Ming M Thomas David L DL Netski Dale M DM Ray Stuart C SC
The Journal of infectious diseases 20081201 11
To determine whether lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticle ...[more]
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