Ontology highlight
ABSTRACT:
SUBMITTER: Won S
PROVIDER: S-EPMC2777973 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Won Sungho S Wilk Jemma B JB Mathias Rasika A RA O'Donnell Christopher J CJ Silverman Edwin K EK Barnes Kathleen K O'Connor George T GT Weiss Scott T ST Lange Christoph C
PLoS genetics 20091126 11
For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditional family-based approaches that are based exclusively on the within-family information. The approach is suitable for the analysis of almost any trait type, e.g. binary, continuous, time-to-onset, multi ...[more]