Ontology highlight
ABSTRACT:
SUBMITTER: Zhang EE
PROVIDER: S-EPMC2777987 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Zhang Eric E EE Liu Andrew C AC Hirota Tsuyoshi T Miraglia Loren J LJ Welch Genevieve G Pongsawakul Pagkapol Y PY Liu Xianzhong X Atwood Ann A Huss Jon W JW Janes Jeff J Su Andrew I AI Hogenesch John B JB Kay Steve A SA
Cell 20090917 1
Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide small interfering RNA screen in a human cellular clock model. Knockdown of nearly 1000 genes reduced rhythm amplitude. Potent effects on period length or increased amplitude were less frequent; we found hundreds of these and confirmed them in secondary screens. Characterization ...[more]