Ontology highlight
ABSTRACT:
SUBMITTER: Org T
PROVIDER: S-EPMC2778368 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Org Tõnis T Rebane Ana A Kisand Kai K Laan Martti M Haljasorg Uku U Andreson Reidar R Peterson Pärt P
Human molecular genetics 20090910 24
The Autoimmune Regulator (AIRE) protein is expressed in thymic medullary epithelial cells, where it promotes the ectopic expression of tissue-restricted antigens needed for efficient negative selection of developing thymocytes. Mutations in AIRE cause APECED syndrome, which is characterized by a breakdown of self-tolerance. The molecular mechanism by which AIRE increases the expression of a variety of different genes remains unknown. Here, we studied AIRE-regulated genes using whole genome expre ...[more]