Ontology highlight
ABSTRACT:
SUBMITTER: Chittasupho C
PROVIDER: S-EPMC2778606 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Chittasupho Chuda C Xie Sheng-Xue SX Baoum Abdulgader A Yakovleva Tatyana T Siahaan Teruna J TJ Berkland Cory J CJ
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090227 2
Interaction of leukocyte function associated antigen-1 (LFA-1) on T-lymphocytes and intercellular adhesion molecule-1 (ICAM-1) on epithelial cells controls leukocyte adhesion, spreading, and extravasation. This process plays an important role in leukocyte recruitment to a specific site of inflammation and has been identified as a biomarker for certain types of carcinomas. Cyclo-(1,12)-PenITDGEATDSGC (cLABL) has been shown to inhibit LFA-1 and ICAM-1 interaction via binding to ICAM-1. In addition ...[more]