Dataset Information

Sex differences in mortality following acute coronary syndromes.

ABSTRACT:

Context

Conflicting information exists about whether sex differences modulate short-term mortality following acute coronary syndromes (ACS).

Objectives

To investigate the relationship between sex and 30-day mortality in ACS, and to determine whether this relationship was modified by clinical syndrome or coronary anatomy using a large database across the spectrum of ACS and adjusting for potentially confounding clinical covariates.

Design, setting, and participants

A convenience sample of patients pooled from 11 independent, international, randomized ACS clinical trials between 1993 and 2006 whose databases are maintained at the Duke Clinical Research Institute, Durham, North Carolina. Of 136 247 patients, 38 048 (28%) were women; 102 004 (26% women) with ST-segment elevation myocardial infarction (STEMI), 14 466 (29% women) with non-STEMI (NSTEMI), and 19 777 (40% women) with unstable angina.

Main outcome measure

Thirty-day mortality following ACS.

Results

Thirty-day mortality was 9.6% in women and 5.3% in men (odds ratio [OR], 1.91; 95% confidence interval [CI], 1.83-2.00). After multivariable adjustment, mortality was not significantly different between women and men (adjusted OR, 1.06; 95% CI, 0.99-1.15). A significant sex by type of ACS interaction was demonstrated (P < .001). In STEMI, 30-day mortality was higher among women (adjusted OR, 1.15; 95% CI, 1.06-1.24), whereas in NSTEMI (adjusted OR, 0.77; 95% CI, 0.63-0.95) and unstable angina, mortality was lower among women (adjusted OR, 0.55; 95% CI, 0.43-0.70). In a cohort of 35 128 patients with angiographic data, women more often had nonobstructive (15% vs 8%) and less often had 2-vessel (25% vs 28%) and 3-vessel (23% vs 26%) coronary disease, regardless of ACS type. After additional adjustment for angiographic disease severity, 30-day mortality among women was not significantly different than men, regardless of ACS type. The relationship between sex and 30-day mortality was similar across the levels of angiographic disease severity (P for interaction = .70).

Conclusions

Sex-based differences existed in 30-day mortality among patients with ACS and vary depending on clinical presentation. However, these differences appear to be largely explained by clinical differences at presentation and severity of angiographically documented disease.

SUBMITTER: Berger JS

PROVIDER: S-EPMC2778841 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sex differences in mortality following acute coronary syndromes.

Berger Jeffrey S JS Elliott Laine L Gallup Dianne D Roe Matthew M Granger Christopher B CB Armstrong Paul W PW Simes R John RJ White Harvey D HD Van de Werf Frans F Topol Eric J EJ Hochman Judith S JS Newby L Kristin LK Harrington Robert A RA Califf Robert M RM Becker Richard C RC Douglas Pamela S PS

JAMA 20090801 8

<h4>Context</h4>Conflicting information exists about whether sex differences modulate short-term mortality following acute coronary syndromes (ACS).<h4>Objectives</h4>To investigate the relationship between sex and 30-day mortality in ACS, and to determine whether this relationship was modified by clinical syndrome or coronary anatomy using a large database across the spectrum of ACS and adjusting for potentially confounding clinical covariates.<h4>Design, setting, and participants</h4>A conveni ...[more]

PMID: 19706861

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Dataset Information

Sex differences in mortality following acute coronary syndromes.

Context

Objectives

Design, setting, and participants

Main outcome measure

Results

Conclusions

Publications

Sex differences in mortality following acute coronary syndromes.

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