Two distinct subtypes of right temporal variant frontotemporal dementia.

ABSTRACT:

Background

Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively distinct behavioral and cognitive symptoms. We aimed to determine whether right temporal FTD is a homogeneous clinical, imaging, and pathologic/genetic entity.

Methods

In this case-control study, 101 subjects with FTD were identified. Atlas-based parcellation generated temporal, frontal, and parietal grey matter volumes which were used to identify subjects with a right temporal dominant atrophy pattern. Clinical, neuropsychological, genetic, and neuropathologic features were reviewed. The subjects with right temporal FTD were grouped by initial clinical diagnosis and voxel-based morphometry was used to assess grey matter loss in the different groups, compared to c

SUBMITTER: Josephs KA 

PROVIDER: S-EPMC2779005 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature