Ontology highlight
ABSTRACT:
SUBMITTER: Ongusaha PP
PROVIDER: S-EPMC2779528 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Ongusaha Pat P PP Kim Hyung-Gu HG Boswell Sarah A SA Ridley Anne J AJ Der Channing J CJ Dotto G Paolo GP Kim Young-Bum YB Aaronson Stuart A SA Lee Sam W SW
Current biology : CB 20061201 24
The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton . The majority of the Rho family proteins function as molecular switches cycling between the active, GTP-bound and the inactive, GDP-bound conformations . Unlike typical Rho-family proteins, the Rnd subfamily members, including Rnd1, Rnd2, RhoE (also known as Rnd3), and RhoH, are GTPase deficient and are thus expected to be constitutively active . Here, we identify an unexpected ro ...[more]