Ontology highlight
ABSTRACT:
SUBMITTER: Faucher F
PROVIDER: S-EPMC2779579 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Faucher Frédérick F Wallace Susan S SS Doublié Sylvie S
DNA repair 20090910 11
7,8-Dihydro-8-oxoguanine (8-oxoG) is the major oxidative product of guanine and the most prevalent base lesion observed in DNA molecules. Because 8-oxoG has the capability to form a Hoogsteen pair with adenine (8-oxoG:A) in addition to a normal Watson-Crick pair with cytosine (8-oxoG:C), this lesion can lead to a G:C-->T:A transversion after replication. However, 8-oxoG is recognized and excised by the 8-oxoguanine DNA glycosylase (Ogg) of the base excision repair pathway. Members of the Ogg1 fa ...[more]