Ontology highlight
ABSTRACT:
SUBMITTER: Hattori K
PROVIDER: S-EPMC2779715 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Hattori Koichi K Heissig Beate B Wu Yan Y Dias Sergio S Tejada Rafael R Ferris Barbara B Hicklin Daniel J DJ Zhu Zhenping Z Bohlen Peter P Witte Larry L Hendrikx Jan J Hackett Neil R NR Crystal Ronald G RG Moore Malcolm A S MA Werb Zena Z Lyden David D Rafii Shahin S
Nature medicine 20020701 8
The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34(+) and mouse Lin(-)Sca-1(+)c-Kit(+) BM-repopulating stem cells, conveying signals for recruitment of HSCs and reconstitution of hematopoiesis. Inhibition of VEGFR1, but not VEGFR2, blocked HSC cell cycling, differentiation and hematopoieti ...[more]