Ontology highlight
ABSTRACT:
SUBMITTER: Bar-Magen T
PROVIDER: S-EPMC2779801 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Bar-Magen Tamara T Sloan Richard D RD Faltenbacher Verena H VH Donahue Daniel A DA Kuhl Björn D BD Oliveira Maureen M Xu Hongtao H Wainberg Mark A MA
Retrovirology 20091111
<h4>Background</h4>Integrase inhibitors are currently being incorporated into highly active antiretroviral therapy (HAART). Due to high HIV variability, integrase inhibitor efficacy must be evaluated against a range of integrase enzymes from different subtypes.<h4>Methods</h4>This study compares the enzymatic activities of HIV-1 integrase from subtypes B and C as well as susceptibility to various integrase inhibitors in vitro. The catalytic activities of both enzymes were analyzed in regard to e ...[more]