Ontology highlight
ABSTRACT:
SUBMITTER: Gutzman JH
PROVIDER: S-EPMC2780020 | biostudies-literature | 2008 Nov-Dec
REPOSITORIES: biostudies-literature
Gutzman Jennifer H JH Graeden Ellie G EG Lowery Laura Anne LA Lowery Laura Anne LA Holley Heidi S HS Sive Hazel H
Mechanisms of development 20080718 11-12
The midbrain-hindbrain boundary (MHB) is a highly conserved fold in the vertebrate embryonic brain. We have termed the deepest point of this fold the MHB constriction (MHBC) and have begun to define the mechanisms by which it develops. In the zebrafish, the MHBC is formed soon after neural tube closure, concomitant with inflation of the brain ventricles. The MHBC is unusual, as it forms by bending the basal side of the neuroepithelium. At single cell resolution, we show that zebrafish MHBC forma ...[more]