Ontology highlight
ABSTRACT:
SUBMITTER: McCulloch DR
PROVIDER: S-EPMC2780442 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
McCulloch Daniel R DR Nelson Courtney M CM Dixon Laura J LJ Silver Debra L DL Wylie James D JD Lindner Volkhard V Sasaki Takako T Cooley Marion A MA Argraves W Scott WS Apte Suneel S SS
Developmental cell 20091101 5
We show that combinatorial mouse alleles for the secreted metalloproteases Adamts5, Adamts20 (bt), and Adamts9 result in fully penetrant soft-tissue syndactyly. Interdigital webs in Adamts5(-/-);bt/bt mice had reduced apoptosis and decreased cleavage of the proteoglycan versican; however, the BMP-FGF axis, which regulates interdigital apoptosis was unaffected. BMP4 induced apoptosis, but without concomitant versican proteolysis. Haploinsufficiency of either Vcan or Fbln1, a cofactor for versican ...[more]