Ontology highlight
ABSTRACT:
SUBMITTER: Urbano JM
PROVIDER: S-EPMC2781052 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Urbano Jose M JM Torgler Catherine N CN Molnar Cristina C Tepass Ulrich U López-Varea Ana A Brown Nicholas H NH de Celis Jose F JF Martín-Bermudo Maria D MD
Development (Cambridge, England) 20091111 24
Laminins are heterotrimeric molecules found in all basement membranes. In mammals, they have been involved in diverse developmental processes, from gastrulation to tissue maintenance. The Drosophila genome encodes two laminin alpha chains, one beta and one Gamma, which form two distinct laminin trimers. So far, only mutations affecting one or other trimer have been analysed. In order to study embryonic development in the complete absence of laminins, we mutated the gene encoding the sole laminin ...[more]