Ontology highlight
ABSTRACT:
SUBMITTER: Botelho RJ
PROVIDER: S-EPMC2781395 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090821 42
We describe a role for diacylglycerol in the activation of Ras and Rap1 at the phagosomal membrane. During phagocytosis, Ras density was similar on the surface and invaginating areas of the membrane, but activation was detectable only in the latter and in sealed phagosomes. Ras activation was associated with the recruitment of RasGRP3, a diacylglycerol-dependent Ras/Rap1 exchange factor. Recruitment to phagosomes of RasGRP3, which contains a C1 domain, parallels and appears to be due to the form ...[more]