Ontology highlight
ABSTRACT:
SUBMITTER: Choi Y
PROVIDER: S-EPMC2781447 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Choi Yongmun Y Seeliger Markus A MA Panjarian Shoghag B SB Kim Hakjoong H Deng Xianming X Sim Taebo T Couch Brian B Koleske Anthony J AJ Smithgall Thomas E TE Gray Nathanael S NS
The Journal of biological chemistry 20090813 42
Allosteric kinase inhibitors hold promise for revealing unique features of kinases that may not be apparent using conventional ATP-competitive inhibitors. Here we explore the activity of a previously reported allosteric inhibitor of BCR-Abl kinase, GNF-2, against two cellular isoforms of Abl tyrosine kinase: one that carries a myristate in the N terminus and the other that is deficient in N-myristoylation. Our results show that GNF-2 inhibits the kinase activity of non-myristoylated c-Abl more p ...[more]