Ontology highlight
ABSTRACT:
SUBMITTER: Peng G
PROVIDER: S-EPMC2781569 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Peng Guangdun G Han Mei M Du Yimin Y Lin Anning A Yu Lei L Zhang Yuqiu Y Jing Naihe N
The Journal of biological chemistry 20090901 44
ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, ...[more]