Ontology highlight
ABSTRACT:
SUBMITTER: Brien G
PROVIDER: S-EPMC2781581 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Brien Gaelle G Debaud Anne-Laure AL Robert Xavier X Oliver Lisa L Trescol-Biemont Marie-Claude MC Cauquil Nicolas N Geneste Olivier O Aghajari Nushin N Vallette Francois M FM Haser Richard R Bonnefoy-Berard Nathalie N
The Journal of biological chemistry 20090915 44
Unlike other antiapoptotic members of the Bcl-2 family, Bfl-1 does not contain a well defined C-terminal transmembrane domain, and whether the C-terminal tail of Bfl-1 functions as a membrane anchor is not yet clearly established. The molecular modeling study of the full-length Bfl-1 performed within this work suggests that Bfl-1 may co-exist in two distinct conformational states: one in which its C-terminal helix alpha9 is inserted in the hydrophobic groove formed by the BH1-3 domains of Bfl-1 ...[more]