Ontology highlight
ABSTRACT:
SUBMITTER: Meier B
PROVIDER: S-EPMC2782091 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Meier Bettina B Barber Louise J LJ Liu Yan Y Shtessel Ludmila L Boulton Simon J SJ Gartner Anton A Ahmed Shawn S
The EMBO journal 20090924 22
The telomerase reverse transcriptase adds de novo DNA repeats to chromosome termini. Here we define Caenorhabditis elegans MRT-1 as a novel factor required for telomerase-mediated telomere replication and the DNA-damage response. MRT-1 is composed of an N-terminal domain homologous to the second OB-fold of POT1 telomere-binding proteins and a C-terminal SNM1 family nuclease domain, which confer single-strand DNA-binding and processive 3'-to-5' exonuclease activity, respectively. Furthermore, tel ...[more]