Expression of GAD67 and novel GAD67 splice variants during human fetal pancreas development: GAD67 expression in the fetal pancreas.
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ABSTRACT:
SUBMITTER: Korpershoek E
PROVIDER: S-EPMC2782109 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Expression of GAD67 and novel GAD67 splice variants during human fetal pancreas development: GAD67 expression in the fetal pancreas.
Korpershoek Esther E Verwest Aart M AM Ijzendoorn Ynske Y Rottier Robbert R Drexhage Hemmo A HA de Krijger Ronald R RR
Endocrine pathology 20070101 1
Glutamic acid decarboxylase (GAD) is a major inhibitory neurotransmitter in the brain, which catalyses the reaction of L-glutamate to gamma-aminobutyric acid. There are two isoforms of GAD, a 65-kDa form and a 67-kDa form, which are encoded by two different genes. As previous studies suggested a role for GAD67 splice variants during fetal pancreas development, we have investigated the mRNA expression of GAD67 and GAD67 splice variants in a series of 14 human fetal pancreases between 14 weeks ges ...[more]
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